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Medizinische Klinik II



Recherche bei pubmed

Über die  pubmed-Datenbank der National Library of Medicine (USA) erhalten Sie einen umfassenden Überblick über Veröffentlichungen von Prof. Dr. Haase.

Publikationen (Auswahl)

Eine Auswahl der Publikationen finden Sie in folgender Veröffentlichungsliste.


  • 61. Streitner I, Goldhofer M, Cho S, Thielecke H, Kinscherf R, Streitner F, Metz J, Haase KK, Borggrefe M, Suselbeck T.
    Electric impedance spectroscopy of human atherosclerotic lesions. Atherosclerosis. 2009 Oct;206(2):464-8. Epub 2009 Mar 25.


  • 60. Herdeg C, Goehring-Frischholz K, Zuern C, Geisler T, Hartmann U, Hoevelborn T, Haase KK, Gawaz M.
    Local catheter-based delivery of antithrombotic or antiproliferative drugs: a new concept for prevention of restenosis. Thromb Res. 2008;123(2):236-43. Epub 2008 May 2.
  • 59. Herdeg C, Geisler T, Goehring-Frischholz K, Zuern C, Hartmann U, Haase KK, Gawaz M. Catheter-based local antiproliferative therapy in kissing balloon technique for in-stent stenosis of coronary artery bifurcation lesions. Can J Cardiol. 2008 Apr;24(4):309-11.


  • 58. Dommke C, Haase KK, Süselbeck T, Streitner I, Haghi D, Metz J, Borggrefe M, Herdeg C. Local paclitaxel delivery after coronary stenting in an experimental animal model. Thromb Haemost. 2007 Sep;98(3):674-80.
  • 57. Herdeg C, Göhring-Frischholz K, Geisler T, May A, Haase KK, Gawaz M. GENIE catheter for liquid local drug delivery. EuroIntervention. 2007 Aug;3(2):286-8.
  • 56. Brueckmann M, Hoffmann U, Engelhardt C, Lang S, Fukudome K, Haase KK, Liebe V, Kaden JJ, Putensen C, Borggrefe M, Huhle G. Prognostic value of platelet-derived growth factor in patients with severe sepsis. Growth Factors. 2007 Feb;25(1):15-24.


  • 55. Kralev S, Poerner TC, Basorth D, Lang S, Wolpert C, Haghi D, Borggrefe M, Haase KK, Süselbeck T. Side branch occlusion after coronary stent implantation in patients presenting with ST-elevation myocardial infarction: clinical impact and angiographic predictors. Am Heart J. 2006 Jan;151(1):153-7.


  • 54. Haghi D, Papavassiliu T, Hach C, Kaden JJ, Kalmar G, Borggrefe M, Haase KK, Sueselbeck T. Utility of combined parameters of common carotid intima-media thickness or albuminuria in diagnosis of coronary artery disease in women. Int J Cardiol. 2005 Nov 2;105(2):134-40.
  • 53. Süselbeck T, Thielecke H, Weinschenk I, Reininger-Mack A, Stieglitz T, Metz J, Borggrefe M, Robitzki A, Haase K.K. In Vivo Intravascular Electric Impedance Spectroscopy Using a New Catheter with Integrated Microelectrodes. Basic Res Cardiol 2005; 100: 28-34
  • 52. Kälsch T, Elmas E, Nguyen XD, Grebert N, Wolpert C, Klüter H, Borggrefe M, Haase KK, Dempfle CE. Enhanced coagulation activation by in vitro lipopolysaccharide-challenge in patients with ventricular fibrillation complicating acute myocardial infarction. J Cardiovasc Electrophysiol 2005; 16: 858-863
  • 51. Haghi D, Papavassiliu T, Hach C, Kaden JJ, Kalmar G, Borggrefe M, Haase KK, Sueselbeck T. Delayed hyperenhancement in a case of Takotsubo cardiomyopathy. Journal of Cardiovascular Magnetic Resonance 2005; 7 (5)
  • 50. Haghi D, Sueselbeck T, Poerner T, Haase KK, Borggrefe M. A Novel Regional Right Ventricular Wall-Motion Abnormality Observed in a Case of Acute Pulmonary Embolism ("Reverse McConnell Sign"). J Am Soc Echocardiogr 2005; 18: 75-77
  • 49. Haghi D, Papavassiliu T, Kalmar G , M. Schroder, W. Neff, JJ. Kaden U Müller U , Haase KK, Borggrefe M, T Suselbeck... A hybrid approach for quantification of aortic valve stenosis using cardiac magnetic resonance imaging and echocardiography. J Cardiovasc Magn Reson 2005;; 7 581-586. (3): 581-6
  • 48. Brueckmann M, Huhle G, Lang S, Haase KK, Bertsch T, Weiß C, Kaden JJ, Putensen C, Borggrefe M. Letter to, Hoffmann U. Prognostic value of plasma N-terminal pro-brain natriuretic peptide in patients with severe sepsis. Circulation 2005; 112: 527-5342005


  • 47. Wolpert C, Kuschyk J, Aramin N, Spehl S, Streitner F, Süselbeck T, Schumacher B, Haase KK, Schimpf R, Borggrefe M. Incidence and Electrophysiological Characteristics of Spontaneous Ventricular Tachyarrhythmias in High Risk Coronary Patients and Prophylactic Implantation of a Defibrillator. Heart 2004; 90: 667-671
  • 46. PapavasiliuT, Wolpert C, Fluchter S, Schimpf R, Neff W, Haase KK, Duber C, Borggrefe M. Magnetic resonance imaging findings in patients with brugada syndrome. J Cardiovasc Electrophysiol. 2004; 15: 1133-8
  • 45. Pörner T., Ludwig B., Duda S., Diesing P., Kalmar G., Süselbeck T., Kaden J., Borggrefe M., Haase K. K.: Determinants of Stent Expansion in Curved Stenotic Lesions: An in Vitro Experimental Study. J Vasc Interv Radiol 2004; 15:000-000
  • 44. Brückmann, M., Hoffmann U., Rossi de L., Weiler H. M., Liebe V., Lang S., Kaden J., Borggrefe M., Haase K. K., Huhle G.: Activated protein C inhibitis the release of macrophage inflammatory protein-1-alpha from THP-1 cells and from human monocytes. Cytokine 26 (2004) 106-113
  • 43. Brückmann M., Wolpert Ch., Bertsch T., Süselbeck T., Liebetrau C., Kaden J., Huhle G., Neumaier M., Borggrefe M., Haase K.K.: Markers of Myocardial Damage, Tissue Healing, and Inflammation after Radiofrequency Catheter Ablation of Atrial Tachyarrhythmias. J Cardiovasc Electrophysiol, Vol. 15, pp. 686-691, 2004
  • 42. Latsch A., Süselbeck, T., Muth A., Pörner T., Baumbach, A., Pfleger S., Borggrefe M., Haase K. K.: Utilization of eptifibatide for treatment of severe dissections as a bail-out procedure. Int. Journal of Cardiology 96 (2004) 229-233
  • 41. Kaden Jens J., Bickelhaupt S., Grobholz R., Haase K. K., Sarikoc A., Kilic R., Brückmann M., Lang M., Zahn I., Vahl C. F., Hagl S., Dempfle C. E., Borggrefe M.: Receptor activator of nuclear factor kappa B ligand and osteoprotegerin regulate aortic valve calcification. J Mol Cell Cardiol 2004; 36:57-66
  • 40. Wolpert C., Kuschyk J., Aramin N., Spehl S., Streitner F., Süselbeck T., Schumacher B., Haase K. K., Schimpf R., Borggrefe M.: Incidence and electrophysiological characteristics of spontaneous ventricular tachyarrhythmias in high risk coronary patients and prophylactic implantation of a defibrillator. Heart 2004; 000:1-6


  • 39. Dempfle C.-E., Kaden J., Haase K. K., Borggrefe M.: Course of indicators of thrombin activity in the early phase of acute myocardial infarction: effect of fibrinolytic therapy and acute percutaneous coronary angioplasty. Thromb Haemost 2003; 147-54
  • 38. Kaden Jens J., Bickelhaupt S., Grobholz R., Brückmann M., Haase Karl K., Dempfle C.-E., Borggrefe M.: Pathogenetic role of chlamydia pneumoniae in calcific aortic stenosis – immunohistochemistry study and review of the literature. J. Heart Valve Dis 2003;12:447-453
  • 37. Kaden Jens J., Dempfle C.E., Grobholz R., Tran H.T., Klikic R., Sarikoc A., Brückmann M., Vahl CF., Hagl S., Haase K.K., Borggrefe M.: Interleukin 1 beta promotes matrix metalloproteinase expression and cell proliferation in calcific aortic stenosis. Atherosclerosis 2003; 170:205-12
  • 36. Brückmann M., Lang S., Borggrefe M., Huhle G., Haase K. K.: Drotrecogin alfa (activated) prolongs half-time of messenger RNA encoding for Interleukin-8 and Monocyte chemoattractant protein-I. Thromb Haemost 2003; 90: 1223-6
  • 35. Wolpert C., Haase K. K., Süselbeck T., Borggrefe M.: Hybrid therapy for atrial fibrillation. Heart Supp. (2003) 5 H51-H55
  • 34. Kaden Jens J., Dempfle C.-E., Grobholz R., Tran H. T., Kiliç R., Sarikoç A., Brückmann M., Vahl C., Hagl S., Haase Karl K., Borggrefe M.: Interleukin-1 Beta Promotes Matrix Metalloproteinase Expression and Cell Proliferation in Calcific Aortic Valve Stenosis. Atherosclerosis 2003; 170:207-14
  • 33. Fischer K. G., Liebe V., Hudek R., Piazolo L., Haase K. K., Borggrefe M., Huhle G.: Anti-hirudin antibodies alter pharmacokinetics and pharmacodynamics of recombinant hirudin. Thromb Haemost 2003; 89: 973-82
  • 32. Duda S.H., Poerner T.C., Wiesinger B., Wiskirchen J., Rundback J. H., Tepe G., Haase K.K.: Drug-eluting Stents: Potential Applications for Peripheral Arterial Occlusive Disease. J Vasc Interv Radiol 2003; 14: 291-301
  • 31. Süselbeck T, Latsch A, von Fürstenberg M, Pörner T, Pfleger S, Wolpert C, Borggrefe M, Haase KK: Comparison of Clinical, Angiographic and Intravascular Ultrasaound Paramters after Direct Stenting versus Predilatation. Am J Cardiol 2003, 91:337-40
  • 30. Brückmann M., Marx A., Weiler H.M., Liebe V., Lang S., Kaden J. J., Zieger W., Borggrefe M., Huhle G., Haase K.K: Stabilization of monocyte chemoattractant protein-1-mRNA by activated protein C. Thromb. and Haemo. 2003; 89: 149 - 160


  • 29. Kaden J., Freyer S., Weisser, G., Willingstorfer W., Bilbal A., Pfleger S., Süselbeck T., Haase K. K., Dempfle C.-E., Borggrefe M.: Correlationof Degree of Aortic Valve Stenosis by Doppler Echocardiogram to Quantity of Calcium in the Valve by Electron Beam Tomography. Am J Cardiol 2002; 90: 554-557
  • 28. Kaden JJ, Freyer S, Weisser G, Willingstorfer W, Bilbal A, Pfleger S, Süselbeck T, Haase KK, Dempfle, C-E, Borggrefe M: Correlation of degree of aortic valve stenosis by doppler echocardiogram to quantify of calcium in the valveby electron beam tomography. Am J Cardiol 2002; 90: 554 – 557
  • 27. Kalmar G, Hübner Friedericke, Voelker W, Hutzenlaub J, Teubner J, Pörner T, Süselbeck T, Borggrefe M, Haase KK: Radial force and wall-apposition of coronary stents in eccentric stenoses: An in-vitro evaluation in a curved vessel model. J Vasc Interven Radiol 2002; 13:499-508
  • 26. Poerner TC, Kralev S, Voelker W, Sueselbeck T, Latsch A, Pfleger S, Schumacher B, Gaudron P, Borggrefe M, Haase KK: Natural history of side branches after coronary stent implantation. Am Heart J 2002; 143 627-35


  • 25. Sueselbeck T, Latsch A, Siri H, Gonska B, Poerner T, Pfleger S, Schumacher B, Borggrefe M, Haase KK: Role of vessel size as a predictor for the occurrence of in-stent restenosis in patients with diabetes. Am J Cardiol 2001; 88: 243-247
  • 24. Kaden JJ, Haase KK, Borggrefe M: Kalzifizierende Aortenklappenstenose: Degeneration oder Atherosklerose. Dtsch. Med. Wochenschr. 2001; 126: 405-407


  • 23. Baumbach A, Herdeg C, Kluge M, Oberhoff M, Lerch M, Haase KK, Wolter C, Schroeder S, Karsch KR: Local drug delivery: impact of pressure, substance characteristics, and stenting on drug transfer into the arterial wall. Catheter Cardiovasc Intervent 1999; 47: 102-6
  • 22. Schroeder S, Baumbach A, Haase KK, Oberhoff M, Marholdt H, Herdeg C, Athanasiadis A, Karsch KR: Reduction of restenosis by vessel size adapted percutaneous transluminal coronary angioplasty using intravascular ultrasound. Am J Cardiol 1999; 83: 875-9
  • 21. Herdeg C, Oberhoff M, Baumbach A, Blattner A, Kuttner A, Schroder S, Haase KK, Karsch KR: Visualization and comparison of drug effects after local paclitaxel delivery with different catheter types. Basic Res Cardiol 1999; 94: 454-63
  • 20. Pfohl M, Koch M, Prescod S, Haase KK, Häring HU, Karsch KR: Angiotensin I-converting enzyme gene polymorphism, coronary artery disease and myocardial infarction. An angiographically controlled study. Eur Heart J 1999; 20: 1318-25
  • 19. Schöbel WA, Voelker W, Haase KK, Karsch KR: Extent, determinants and clinical importance of pressure recovery in patients with aortic valve stenosis. Eur Heart J 1999; 20: 1355-1363
  • 18. Haase KK, Mahrholdt H, Athanasidis A, Baumbach A, Oberhoff M, Herdeg C, Karsch KR: Frequency and efficacy of GP IIb/IIIa therapy for treatment of acute or threatened vessel closure in 1500 patients undergoing PTCA. Am Heart J 1999; 137: 234-40


  • 17. Oberhoff M, Novak S, Herdeg C, Baumbach A, Kranzhöfer A, Bohnet A, Horch B, Hanke H, Haase KK, Karsch KR: Local and systemic delivery of low molecular weight heparin stimulates the reendothelialization after balloon angioplasty. Cardiovasc Research 1998; 38: 751-62
  • 16. Oberhoff M, Baumbach A, Hermann T, Diehl C, Maier R, Athanasiadis A, Herdeg C, Bohnet A, Haase KK, Voelker W, Baildon R, Veldhof S, Karsch KR: Local and systemic delivery of low molecular weight heparin following PTCA: Acute results and 6-month follow-up of the initial clinical experience with the porous balloon (PILOT-Study). Cathet Cardiovasc Diagn 1998; 44: 267-74
  • 15. Schöbel W, Voelker W, Obergfell S, Haase KK, Karsch KR: Accuracy of computer-based quantification of aortic valve stenosis. Cath Cardiovasc Diag 1998;
  • 14. Athanasiadis A, Haase KK, Wullen B, Treusch AW, Mahrholdt A, Voelker W, Baumbach A, Oberhoff M, Karsch KR: Lesion morphology assessed by pre-interventional intravascular ultrasound does not predict the incidence of severe coronary artery dissections; Eur Heart J 1998; 19: 870-78
  • 13. Haase KK, Athanasiadis A, Mahrholdt H, Treusch A, Wullen B, Jaramillo C, Baumbach A, Voelker W, Meisner C, Karsch KR: Acute and one year follow-up results after vessel size adapted PTCA using intracoronary ultrasound. Eur Heart J 1998; 19: 263-72

1989 - 1997

  • 12. Herdeg C, Oberhoff M, Baumbach A, Haase KK, Horch B, Kranzhoefer A, Karsch KR: Local drug delivery with porous balloons in the rabbit: assessment of vascular injury for an improvement of application parameters. Cathet Cardiovasc Diagn, 1997; 41: 308-14
  • 11. Baumbach A, Oberhoff M, Bohnet A, Miljak T, Herdeg C, Horch B, Blessing E, Kunert W, Haase KK, Karsch KR: Efficacy of low-molecular-weight heparin delivery with the dispatch catheter following balloon angioplasty in the rabbit iliac artery. Cathet Cardiovasc Diagn 1997; 41: 303-07
  • 10. Hanke H, Hassenstein S, Kamenz J, Oberhoff M, Haase KK, Baumbach A, Betz E, Karsch KR: Prolonged proliferative response of smooth muscle cells after experimental intravascular stenting. Eur Heart J 1995; 16: 785-793
  • 9. Hanke H, Hassenstein S, Ulmer A, Kamenz J, Oberhoff M, Haase KK, Baumbach A, Gown AM, Karsch KR: Accumulation of macrophages in the arterial vessel wall following experimental balloon angioplasty. Eur Heart J 1994; 15: 691-698
  • 8. Schmid KM, Haase KK, Steufmehl G, Voelker W, Fenchel G, Seboldt H, Hoffmeister HE, Karsch KR: Komplementäre Anwendung von perkutaner transluminaler Ballonangioplastie (PTCA) und aortokoronarer Bypass-Operation (ACB) bei medikamentös intraktabler Angina pectoris (Hochrisiko-Gruppe). Z Herz Thorax Gefäßchir 1993; 7: 59-64
  • 7. Voelker W, Berner A, Regele B, Schmid M, Dittmann H, Stötzer T, Haase KK, Baumbach A, Karsch KR: Effect of excercise on valvular resistance in patients with mitral stenosis. J Am Coll Cardiol 1993; 22: 777-782
  • 6. Baumbach A, Haase KK, Voelker W, Mauser M, Karsch KR: Effects of intracoronary nitroglycerin on lumen diameter during early follow-up angiography after coronary laser atherectomy. Eur Heart J 1991; 12: 726-731
  • 5. Hanke H, Haase KK, Hanke S, Oberhoff M, Hassenstein S, Betz E, Karsch KR: Morphological changes and smooth muscle cell proliferation following experimental excimer laser treatment. Circulation 1991; 83: 1380-1389
  • 4. Karsch KR, Haase KK, Voelker W, Baumbach A, Mauser M, Seipel L: Percutaneous coronary excimer laser angioplasty in patients with stable and unstable angina pectoris - Acute results and incidence of restenosis at 6 month follow-up. Circulation 1990; 81: 1849-1859
  • 3. Karsch KR, Haase KK, Mauser M, Voelker W: Initial angiographic results in ablation of atherosclerotic plaques by percutaneous coronary excimer laser angioplasty without subsequent balloon dilatation. Am J Cardiol 1989; 64: 1253-1257
  • 2. Karsch KR, Haase KK, Mauser M, Ickrath O, Voelker W, Duda S, Seipel L: Percutaneous coronary excimer laser angioplasty: Initial clinical results. Lancet 1989; 8664: 647-650
  • 1. Karsch KR, Haase KK, Mauser M, Ickrath O, Voelker W, Duda S, Seipel L: Perkutane transluminale koronare Excimer-Laserangioplastie. Dtsch. med. Wschr. 1989; 114: 1183-1187